Cutaneous infiltrates of histiocytosis X contain plasminogen activator-bearing epidermotropic dendritic cells different from Langerhans cells

@article{Burg1987CutaneousIO,
  title={Cutaneous infiltrates of histiocytosis X contain plasminogen activator-bearing epidermotropic dendritic cells different from Langerhans cells},
  author={Guenter Burg and Karin St{\"u}nkel and Thomas Bieber and Uta Opitz and Peter Kaudewitz},
  journal={Archives of Dermatological Research},
  year={1987},
  volume={279},
  pages={S88-S91}
}
Plasminogen activators (PA) play an important role in cell migration and tissue degradation. Considering the strong epidermotropism of atypical mononuclear cells in histiocytosis X (HX) skin infiltrates leading to intraepidermal abscess formation, it was the purpose of this study to look for tissue-type PA (t-PA) and/or urokinase-type PA (u-PA) on HX cells. Four monoclonal antibodies against PA were used, employing the alkaline phosphatase anti-alkaline phosphatase (APAAP) technique on cryostat… CONTINUE READING