Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines.

@article{Mori2008CutaneousHT,
  title={Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines.},
  author={Tomoko Mori and Kenji Kabashima and Ryutaro Yoshiki and Kazunari Sugita and Noriko Shiraishi and Ayako Onoue and Etsushi Kuroda and Miwa Kobayashi and Uki Yamashita and Yoshiki Tokura},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 7},
  pages={1719-27}
}
There are immediate, late-phase, and delayed-type reactions to exogenous agents. In IFN-gamma-knockout (IFN-gamma(-/-)) and wild-type B6 mice, we examined the response to picryl chloride (PCl) for assessing delayed-type reactions, and the responses to repeatedly challenged FITC for immediate and late-phase reactions. The delayed-type hypersensitivity was depressed in IFN-gamma(-/-) mice, and the immediate and late-phase reactions were enhanced in IFN-gamma(-/-) mice. As skin-infiltrating… CONTINUE READING

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