Cutaneous fibrinolytic activity in primary hypertrophic osteoarthropathy.


Cutaneous fibrinolytic activity was investigated in 13 patients affected with Primary Hypertrophic Osteoarthropathy in the advanced phase. Biopsies were taken from periungueal skin of the ippocratic finger and from the dorsum of the first phalanx: cutaneous fibrinolytic activity was investigated with Todd's autohistographic method as modified by Lotti et al., showing increased activity in periungueal skin (10/13) and normal in the apparently uninvolved skin (9/13). We suggest that the increase in plasminogen activator activity, in the advanced phase of the disease, may be related to the increased growth of the connective tissue that is characteristic of the disease.


Citations per Year

203 Citations

Semantic Scholar estimates that this publication has 203 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{MatucciCerinic1987CutaneousFA, title={Cutaneous fibrinolytic activity in primary hypertrophic osteoarthropathy.}, author={Marco Matucci-Cerinic and Torello Maria Lotti and Ines Jaji{\'c} and Simonetta di Lollo and Luigi Brunetti and Dejan Orli{\'c}}, journal={Scandinavian journal of rheumatology}, year={1987}, volume={16 3}, pages={205-12} }