Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.

@article{Smith2003CutaneousEO,
  title={Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.},
  author={Gill Smith and C. R. Wolf and Yusuf Y Deeni and Robert Dawe and A. Thomas Evans and Muriel M. Comrie and James Ferguson and Sally Helen Ibbotson},
  journal={Lancet},
  year={2003},
  volume={361 9366},
  pages={1336-43}
}
BACKGROUND Treatment of common skin diseases such as psoriasis is complicated by differences between individuals in response to topical drug treatment and photochemotherapy. Individuality in hepatic expression of drug-metabolising enzymes is an important determinant of systemic drug handling; we investigated whether similar variation in cutaneous gene expression contributes to individuality in response to topical therapies. METHODS We used quantitative real-time RT-PCR to demonstrate the… CONTINUE READING