Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma.

@article{Hantschke2010CutaneousCC,
  title={Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma.},
  author={Markus Hantschke and Thomas Mentzel and Arno Ruetten and Gabriele Palmedo and Eduardo J Calonje and Alexander J Lazar and Heinz Kutzner},
  journal={The American journal of surgical pathology},
  year={2010},
  volume={34 2},
  pages={216-22}
}
Clear cell sarcoma (CCS) of tendons and aponeuroses/malignant melanoma (MM) of soft parts is a rare tumor and in the majority of cases presents a characteristic reciprocal translocation t(12;22)(q13;q12) that results in fusion of the EWS and ATF1 genes. Although the melanocytic differentiation of CCS is indisputable, its precise lineage remains unclear. Typically, the slowly growing tumor affects the extremities of adolescents or young adults, especially around the ankle and foot. CCS is… CONTINUE READING
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