Cutaneous androgen metabolism: basic research and clinical perspectives.

  title={Cutaneous androgen metabolism: basic research and clinical perspectives.},
  author={Wenchieh Chen and Diane M. Thiboutot and C C Zouboulis},
  journal={The Journal of investigative dermatology},
  volume={119 5},
The skin, especially the pilosebaceous unit composed of sebaceous glands and hair follicles, can synthesize androgens de novo from cholesterol or by locally converting circulating weaker androgens to more potent ones. As in other classical steroidogenic organs, the same six major enzyme systems are involved in cutaneous androgen metabolism, namely steroid sulfatase, 3beta-hydroxy-steroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, steroid 5alpha-reductase, 3alpha-hydroxysteroid… CONTINUE READING


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