Cutaneous and systemic responses during primary and challenge infestations of sheep with the sheep scab mite, Psoroptes ovis

@article{Broek2000CutaneousAS,
  title={Cutaneous and systemic responses during primary and challenge infestations of sheep with the sheep scab mite, Psoroptes ovis},
  author={M. van den Broek and Huntley and Machell and Taylor and Bates and Groves and Miller},
  journal={Parasite Immunology},
  year={2000},
  volume={22}
}
Lesional area was estimated and lesional mast cells and eosinophils were counted during primary and challenge infestations of sheep with Psoroptes ovis. In addition, circulating basophils and eosinophils and serum P. ovis‐specific immunoglobulin IgE antibody were quantified. Expansion of lesional area was significantly less and serum IgE titres significantly greater in challenge than primary infestations. Lesional mast cell hyperplasia and massive eosinophil infiltration accompanied by raised… Expand
Temporal pattern of isotype-specific antibody responses in primary and challenge infestations of sheep with Psoroptes ovis--the sheep scab mite.
TLDR
Antigen-specific enzyme-linked immunosorbent assays (ELISAs) demonstrate that primary infestations elicited significant increases in levels of IgG and IgM but not IgA antibodies, and these antigens/allergens may be exploited in immunodiagnosis and modulation of the host immune response. Expand
Early innate and longer-term adaptive cutaneous immunoinflammatory responses during primary infestation with the sheep scab mite, Psoroptes ovis.
Clinical observation has indicated that Psoroptes ovis mites provoke cutaneous inflammation within hours of experimental infestation, but the nature of this reaction has not been described. AfterExpand
Cutaneous hypersensitivity reactions to Psoroptes ovis and Der p 1 in sheep previously infested with P. ovis--the sheep scab mite.
TLDR
Results suggest that P. ovis allergens provoke an IgE-dependent immediate and late phase response and a cell-mediated eosinophil-rich delayed-type hypersensitivity response (ER-DTH). Expand
Characterisation of lesional infiltrates of dendritic cells and T cell subtypes during primary infestation of sheep with Psoroptes ovis, the sheep scab mite.
TLDR
The observations suggest that mite-derived products exert a profound influence on the early recruitment of lymphocytes that may significantly influence the genesis of the adaptive immune response. Expand
Infestation of sheep with Psoroptes ovis, the sheep scab mite, results in recruitment of Foxp3+ T cells into the dermis
TLDR
It is demonstrated that infestation of sheep with P. ovis results in an influx of Foxp3+ T cells into the skin, and it is hypothesized that Tregs are involved in sheep scab lesions and Treg responses may crucially affect lesion development and subsequent mite survival. Expand
Dermal immune responses against Psoroptes ovis in two cattle breeds and effects of anti-inflammatory dexamethasone treatment on the development of psoroptic mange
TLDR
Results suggest that a stronger Th2-type immune response to P. ovis causes the skin lesions in psoroptic mange in BB cattle and that local anti-inflammatory treatment could potentially be an alternative to control the pathology caused by this parasite. Expand
Stimulation of the In Vitro Migration of Ovine Eosinophils by Factors Derived from the Sheep Scab Mite, Psoroptes ovis
TLDR
The finding that mite-derived factors directly enhance the migration of ovine eosinophils in vitro raises the possibility that mites could directly influence, perhaps even initiate, the rapid early tissue eOSinophilic response observed in experimental sheep scab infections. Expand
An immunohistochemical assessment of the cutaneous immune response to louse infestation in cattle.
TLDR
The increased number of lymphocytes and antigen-presenting cells observed in the present study suggests that in chronic infestation there is activation of local cell-mediated (Th1) immunity. Expand
Immune responses to Staphylococcus aureus and Psoroptes ovis in sheep infected with P. ovis--the sheep scab mite.
TLDR
In sheep, lesions caused by Psoroptes ovis, the sheep scab mite, may become colonized by Staphylococcus aureus, and 6 weeks after infestation an IgE response to P. ovis was detected in the S. a Aureus-positive but not theS. Expand
Identification of an antigen from the sheep scab mite, Psoroptes ovis, homologous with house dust mite group I allergens
TLDR
In enzyme‐linked immunosorbent assays, a pronounced IgG‐antibody response to Pso o 1 was detected in five of five sheep 3 weeks postinfestation, and a marked IgE response occurred in the fifth animal, and IgE anti Pso mite allergens were detected in the serum. Expand
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