Cutaneous T-cell lymphoma: roles for chemokines and chemokine receptors.

  title={Cutaneous T-cell lymphoma: roles for chemokines and chemokine receptors.},
  author={Xue-Song Wu and A S Lonsdorf and Sam Hwang},
  journal={The Journal of investigative dermatology},
  volume={129 5},
Chemokine receptors are G-protein-coupled, seven-transmembrane-spanning surface receptors that play key roles in cell trafficking, cell motility, and survival. These receptors are activated by small molecular weight chemotactic cytokines called chemokines. Chemokine receptors play roles in the migration and localization of normal T cells (and other leukocytes) during physiological responses in inflamed or infected skin. In cancer cells, these receptors may also facilitate tumorigenesis… CONTINUE READING