Cutaneous Human Papillomavirus E7 Type-Specific Effects on Differentiation and Proliferation of Organotypic Skin Cultures

@inproceedings{Westphal2009CutaneousHP,
  title={Cutaneous Human Papillomavirus E7 Type-Specific Effects on Differentiation and Proliferation of Organotypic Skin Cultures},
  author={Kathi Westphal and Baki Akg{\"u}l and Alan Storey and Ingo 4 Nindl},
  booktitle={Cellular oncology : the official journal of the International Society for Cellular Oncology},
  year={2009}
}
BACKGROUND A role for cutaneous human beta-papillomavirus (HPV) types as co-factors in the development of non-melanoma skin cancer has been postulated. Here we have investigated the effects of E7 expression on keratinocyte differentiation, proliferation and cell-cycle proteins in organotypic skin cultures. METHODS Recombinant retroviruses containing the E7 genes from cutaneous HPV types 1, 4, 5, 8, 20, 38 and RTRX7 were produced that include types associated with benign and malignant lesions… CONTINUE READING

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