Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2

  title={Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2},
  author={Dorothea Muschik and Ilona Braspenning-Wesch and E Stockfleth and Frank R{\"o}sl and Thomas G. Hofmann and Ingo 4 Nindl},
  booktitle={PloS one},
Ultraviolet irradiation (UV) is the major risk factor for the development of skin cancer. Moreover, increasing evidence suggests cutaneotropic human papillomaviruses (HPV) from the beta genus to play a causal role as a co-factor in the development of cutaneous squamous cell carcinoma. Homeodomain-interacting protein kinase 2 (HIPK2) operates as a potential suppressor in skin tumorigenesis and is stabilized by UV-damage. HIPK2 is an important regulator of apoptosis, which forms a complex with… CONTINUE READING
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