Cutaneous Epithelial Tumors Induced by Vemurafenib Involve the MAPK and Pi3KCA Pathways but Not HPV nor HPyV Viral Infection

@inproceedings{Frouin2014CutaneousET,
  title={Cutaneous Epithelial Tumors Induced by Vemurafenib Involve the MAPK and Pi3KCA Pathways but Not HPV nor HPyV Viral Infection},
  author={{\'E}ric Frouin and Bernard Guillot and Marion Larrieux and Ariane Tempier and Nathalie Boulle and Vincent Foulongne and C Girard and Val{\'e}rie Costes and J{\'e}r{\^o}me Solassol},
  booktitle={PloS one},
  year={2014}
}
The inhibitors of mutant BRAF that are used to treat metastatic melanoma induce squamoproliferative lesions. We conducted a prospective histopathological and molecular study on 27 skin lesions from 12 patients treated with vemurafenib. Mutation hot spots in HRAS, NRAS, KRAS, BRAF, and Pi3KCA were screened. HPV and HPyV infection status were also determined. The lesions consisted of 19 verrucal papillomas, 1 keratoacanthoma and 7 squamous cell carcinomas. No mutations were found within BRAF and… CONTINUE READING