Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.

@article{Tan2012CutaneousP,
  title={Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.},
  author={Min Jie Alvin Tan and Elizabeth A. White and Mathew E. Sowa and J Wade Harper and Jon C Aster and Peter M. Howley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 23},
  pages={E1473-80}
}
The Notch signaling pathway is a key determinant in keratinocyte differentiation and growth cycle arrest, and has been reported to have a tumor suppressor function in skin. The papillomavirus life cycle is intricately linked to the differentiation status of keratinocytes. Papillomaviruses are associated with benign proliferative epithelial lesions in their respective hosts. Although human papillomaviruses (HPVs) associated with genital tract lesions have been extensively studied, studies of the… CONTINUE READING
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