Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification.

@article{Oberthuer2006CustomizedOM,
  title={Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification.},
  author={Andr{\'e} Oberthuer and Frank Berthold and Patrick Warnat and Barbara Hero and Yvonne Kahlert and Ruediger Spitz and Karen Ernestus and Rainer Koenig and Stefan Haas and Roland Eils and Manfred Schwab and Benedikt Brors and Frank Westermann and Matthias Hermann Fischer},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 31},
  pages={
          5070-8
        }
}
PURPOSE To develop a gene expression-based classifier for neuroblastoma patients that reliably predicts courses of the disease. PATIENTS AND METHODS Two hundred fifty-one neuroblastoma specimens were analyzed using a customized oligonucleotide microarray comprising 10,163 probes for transcripts with differential expression in clinical subgroups of the disease. Subsequently, the prediction analysis for microarrays (PAM) was applied to a first set of patients with maximally divergent clinical… CONTINUE READING

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