Curve-fitting in pharmacokinetics — A comparison between gamma-and biexponential fits


Seven sets of plasma concentration-time data were fitted to both a conventional biexponential equation and a gamma equation. The values of clearance (CL) and mean residence time (MRT) were calculated from the fitted parameters and compared with the values calculated by the trapezoid rule. Both the biexponential and gamma equations provided adequate fits to… (More)
DOI: 10.1007/BF00614312

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