Curvature of mouse satellite DNA and condensation of heterochromatin

  title={Curvature of mouse satellite DNA and condensation of heterochromatin},
  author={Marko Z. Radic and Karen Lundgren and Barbara A. Hamkalo},
Cloned, sequenced mouse satellite DNA exhibits properties characteristic of molecules that possess a stable curvature. Circularly permuted fragments containing the region predicted to bend were used to map the curvature relative to DNA sequence. The altered mobility of these fragments in polyacrylamide gels is reversed when gels are run in the presence of distamycin A, a drug that binds preferentially to AT-rich DNA. Treatment of living mouse cells with this drug dramatically reduces the… CONTINUE READING


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