Currents through the fusion pore that forms during exocytosis of a secretory vesicle

@article{Breckenridge1987CurrentsTT,
  title={Currents through the fusion pore that forms during exocytosis of a secretory vesicle},
  author={L. J. Breckenridge and Wolfhard Almers},
  journal={Nature},
  year={1987},
  volume={328},
  pages={814-817}
}
Exocytosis, or the fusion of cytoplasmic vesicles with the cell membrane, occurs in nearly all eukaryotic cells, but its mechanism is not understood. Morphological1,2 and electrophysiological studies3–5 have suggested that membrane fusion begins with the formation of a 'fusion pore', a narrow channel across the closely adjacent membranes of vesicle and cell that forms the first connection of the vesicle lumen with the cell exterior and later dilates to allow release of vesicle contents. We used… 
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Results show that ‘kiss-and-run’ fusion occurs at synapses and that it can generate rapid postsynaptic currents, and suggest that various fusion pore sizes help to control the kinetics and amplitude of synaptic currents.
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