Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells.

@article{Howe1991CurrentsTS,
  title={Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells.},
  author={James R. Howe and Stuart G Cull-Candy and David Colquhoun},
  journal={The Journal of physiology},
  year={1991},
  volume={432},
  pages={143-202}
}
1. Single-channel currents evoked in outside-out membrane patches from rat cerebellar granule cells by glutamate, aspartate, N-methyl-D-aspartate (NMDA), kainate and quisqualate were studied. Each agonist produced openings to five discrete amplitude levels. At a membrane potential of -70 mV, these levels correspond to single-channel conductances of about 8, 17, 30, 40 and 50 pS. NMDA, aspartate and glutamate evoked mainly 50 pS openings and also substantial numbers of 40 pS events. Kainate… CONTINUE READING

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