Currents Related to Movement of the Gating Particles of the Sodium Channels

@article{Armstrong1973CurrentsRT,
  title={Currents Related to Movement of the Gating Particles of the Sodium Channels},
  author={Clay M. Armstrong and Francisco Bezanilla},
  journal={Nature},
  year={1973},
  volume={242},
  pages={459-461}
}
“…IT seems difficult to escape the conclusion that the changes in ionic permeability depend on the movement of some component of the membrane which behaves as though it had a large charge or dipole moment”1. With these words Hodgkin and Huxley predicted the existence of gating currents: charge movement associated with molecular rearrangements that attend the opening and closing of the ionic channels in response to changes in the membrane field. The polarity of gating current of the sodium… 
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