Current-voltage relationship of the basolateral membrane of a tight epithelium.

  title={Current-voltage relationship of the basolateral membrane of a tight epithelium.},
  author={Nancy K. Wills and Douglas C. Eaton and Simon A. Lewis and Mark S. Ifshin},
  journal={Biochimica et biophysica acta},
  volume={555 3},
The polyene antibiotic nystatin is used to reduce selectively to zero the apical membrane resistance of the rabbit descending colon, allowing the measurement of the current-voltage curve of the basolateral membrane. The I--V relationship is described by the Goldman-Hodgkin-Katz equations allowing calculation of PNa/PK, PCl/PK and PK for the basolateral membrane. Cs+ is found to block inward current (serosa to mucosa) in a manner similar to that found in excitable membranes. 

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