Current views on the diagnosis and management of hypokalaemia in children

  title={Current views on the diagnosis and management of hypokalaemia in children},
  author={Jakub Zieg and Lucie Gonsorc{\'i}kov{\'a} and Daniel Landau},
  journal={Acta Paediatrica},
Hypokalaemia is a common electrolyte disorder in children, caused by decreased potassium intake, increased gastrointestinal and urinary losses or transcellular shift. Patients with severe hypokalaemia may suffer from symptoms such as life‐threatening cardiac arrhythmias. The aim of our study was to review the aetiology of hypokalaemia, suggest a diagnostic algorithm and discuss the management of patients with various aetiologies of hypokalaemia. 
Associated Diagnoses, Treatment and Outcomes of Children with Hypokalemia
Hypokalemia was more severe in patients diagnosed during admission; these patients also experienced longer hospital stays and two patients in each group required rapid potassium infusions.
In the presence of hypokalemia and hypomagnesemia; remember Gitelman syndrome.
This lifelong disease could cause life-threatening conditions due to the cardiac complications of hypokalemia in some of the affected patients and it is necessary to be aware of the appropriate diagnosis and treatment for patients admitted to the clinic with hypokAlemia, hypomagnesemia,hypocalciuria, and hyperreninemia.
Early management of hypokalaemia in severely malnourished children under five could help to reduce deaths in developing countries
This study evaluated the factors associated with hypokalaemia and their outcomes, in severely malnourished children under 5 years of age.
A Rare Cause of Chronic Hypokalemia with Metabolic Alkalosis: Case Report and Differential Diagnosis
The case of a child presenting with failure to thrive associated with early detection of hypokalemia, metabolic alkalosis, nephrocalcinosis and hypertension in which AME syndrome was detected is reported.
Ventricular bigeminy and trigeminy caused by hypophosphataemia during diabetic ketoacidosis treatment: a case report
Ventricular arrhythmia was observed in a 10-year-old girl with newly diagnosed type 1 diabetes mellitus and hypophosphatemia while undergoing treatment for ketoacidosis, and oral phosphate supplementation ceased ventricular arrHythmia almost completely.
This study highlights the need to understand more fully the rationale behind the continued presence of neonatal intensive care units in the neonate intensive care unit.
Functional Study of Novel Bartter’s Syndrome Mutations in ClC-Kb and Rescue by the Accessory Subunit Barttin Toward Personalized Medicine
Results confirm a genotype-phenotype correlation in BS and represent a preliminary proof of concept that molecules functioning as molecular chaperones can restore channel function in expression-defective ClC-Kb mutants.
A Novel Frameshift Mutation of SCNN1G Causing Liddle Syndrome with Normokalemia
This case emphasizes that once a proband is diagnosed with LS by genetic testing, family genetic sequencing is necessary for early diagnosis and intervention for other family members, to protect against severe cardiovascular complications.
Pharmacovigilance database search discloses ClC‐K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan
The aim of this study was to identify novel ClC‐K ligands from drugs already on the market, by exploiting the pharmacological side activity of drug molecules available from the FDA Adverse Effects Reporting System database.
Ion Channels in Drug Discovery and Safety Pharmacology.
Two examples of how the combination of in silico methods and patch clamp experiments can help addressing drug discovery and safety issues regarding ion channels are discussed.


Disorders of potassium.
Pathogenesis, diagnosis and management of hyperkalemia
Treatment has to be initiated immediately using different therapeutic strategies to increase potassium shift into the intracellular space or to increase elimination, together with reduction of intake.
Cola-induced hypokalemia-a case report and review of the literature.
  • Rajeev Sharma, H. Guber
  • Medicine, Biology
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2013
Ingestion of large quantities of cola should be added to differential diagnosis for severe hypokalemia through several pathophysiologic mechanisms.
Electrolyte disorders.
Genetic disorders of potassium homeostasis.
Mechanism of hypokalemia in magnesium deficiency.
Books suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion are reviewed, suggesting that an increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.
Toluene induced hypokalaemia: case report and literature review
A case is presented of toluene induced hypokalaemia in a 22 year old woman who presented with generalised weakness.
Transient neonatal hyperkalemia in the antenatal (ROMK defective) Bartter syndrome.
Early postnatal hyperkalemia, sometimes severe, may complicate antenatal BS associated with ROMK mutations, and its association with hyponatremia and hyperreninemic hyperaldosteronism may erroneously suggest the diagnosis of pseudohypoaldoster onism type 1.
Thyrotoxic, hypokalemic periodic paralysis (THPP) in adolescents
THPP's occurrence in three Hispanic adolescent males suggests that it may occur more frequently in the young and in the USA than has been suspected, especially with the changing national demographics.
Bartter syndrome: benefits and side effects of long-term treatment
The present study reports clinical and laboratory data of patients with Bartter syndrome at diagnosis and follow-up with emphasis on the long-term benefits and side effects of the pharmacological