• Corpus ID: 79448189

Current views on etiology of alopecia areata

  title={Current views on etiology of alopecia areata},
  author={Ewa Joss-Wichman and Grażyna Broniarczyk-Dyła},
Alopecia areata (AA) is a common disease of the skin, constituting about 2% of all dermatoses. It occurs in humans, but also other mammals and may develop at any age. The disease can present with two main forms – AA vulgaris (AAV) and AA totalis/universalis (AAT/U). Current views on etiology of this condition are presented in the paper. On the base of modern literature the most popular etiological theories, explaining the pathomechanism of hair loss, are discussed. These include autoimmune… 

The role of selectins in alopecia areata

Serum concentrations of soluble forms of E- and L-selectins correlated with the severity of the disease, while E-selectin with activity of AA is shown to play an important role in the pathogenesis of AA.

Assessment of Serum Levels of E-Selectin and L-Selectin in Alopecia Areata

This study showed that sE-selectin and sL- selectin may play a significant role in the pathogenesis of AA and might open a way to future treatments for this disease.



Alopecia areata.

Alopecia areata is an asymptomatic, nonscarring hair loss with spontaneous remissions and exacerbations that is associated with vitiligo, atopy, pernicious anemia, Down syndrome and thyroiditis.

Alopecia areata update.

Treatment with intralesional corticosteroid injections for localized patchy AA and topical immunotherapy for extensive AA have proven successful in the majority of patients, although all treatments are palliative and do not change the prognosis of the disease.

A natural canine homologue of alopecia areata in humans

Alopecia areata is suspected to be an autoimmune disease directed preferentially against hair follicles affecting both humans and various mammalian species and it is not known whether dogs with AA could be useful as an outbred homologue of this disease in humans.

Alopecia areata: pathogenesis and treatment.

The pathogenesis of alopecia areata in rodent models.

Manipulation of inflammatory cells in vivo indicates alopecia areata is primarily a cell mediated disease with auto-antibody production as a secondary event, and a self contained disease cycle involving four key events.

Alopecia areata susceptibility in rodent models.

With our current view of alopecia areata as an autoimmune disease, it is probable that disease development in an individual is dependent on multiple genetic and environmental factors interacting in a

Autoimmunity: alopecia areata.

Testing the efficacy of the newly developed immunomodulatory agents in patients with alopecia areata may lead to the introduction of novel therapies for this immune-mediated disease of the hair follicle.

Genetic linkage studies in alopecia areata.

The approach to the identification of susceptibility genes for alopecia areata is discussed, which aims to provide a foundation for understanding how they interact with each other and with other variables, such as the immune system and environmental factors.


The results are logically interpreted to mean that a wave of hair follicle damage or arrest moves centrifugally from a focal point beyond the area of alopecia.

Immunity to hair follicles in alopecia areata.

The large cell-surface to volume ratio of melanocytes may well make them exhibit early signs of general distress in the follicle, perhaps due to perturbance of the normal regnlatory factors produced by the dermal papilla.