Current understanding of the mechanism of action of the antiepileptic drug lacosamide

@article{Rogawski2015CurrentUO,
  title={Current understanding of the mechanism of action of the antiepileptic drug lacosamide},
  author={Michael A Rogawski and Azita Tofighy and H. Steve White and Alain Matagne and Christian Wolff},
  journal={Epilepsy Research},
  year={2015},
  volume={110},
  pages={189-205}
}
  • Michael A Rogawski, Azita Tofighy, +2 authors Christian Wolff
  • Published in Epilepsy Research 2015
  • Chemistry, Medicine
  • The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test. Attention was drawn to lacosamide because of its high oral potency and stereoselectivity. Lacosamide is also active in the 6 Hz seizure model but inactive against clonic seizures in rodents induced by subcutaneous pentylenetetrazol, bicuculline and picrotoxin. It is also… CONTINUE READING

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