Current understanding of delayed anticonvulsant hypersensitivity reactions.

@article{Krauss2006CurrentUO,
  title={Current understanding of delayed anticonvulsant hypersensitivity reactions.},
  author={Gregory L. Krauss},
  journal={Epilepsy currents},
  year={2006},
  volume={6 2},
  pages={33-7}
}
Hypersensitivity syndrome (HSS) reactions are one of the most feared idiosyncratic drug reactions and are most common with exposure to antiepileptic drugs (AEDs), sulfonamides, nonsteroidal antiinflammatory drugs, corticosteroids, and allopurinol. HSS is associated with chemotoxic and T-cell-mediated inflammatory injuries in barrier tissue systems that contain cytochrome oxidases (e.g., skin, mucosa, liver, and lungs) and can be seen as a derangement in the defense system against xenobiotics… CONTINUE READING