Current treatment of sepsis and endotoxaemia.

  title={Current treatment of sepsis and endotoxaemia.},
  author={Piero Periti},
  journal={Expert opinion on pharmacotherapy},
  volume={1 6},
  • Piero Periti
  • Published 2000 in Expert opinion on pharmacotherapy
This article reviews the new criteria for selecting the proper antimicrobial agent and dosage regimen for standard treatment of severe sepsis, with the intention of preventing septic shock. After introducing new concepts on the pathogenesis of sepsis and septic shock, the authors analyse the parameters of beta-lactam antibacterial activity, the antibiotic-induced release of bacterial endotoxin and the interrelationships between pharmacokinetics and pharmacodynamics of antibiotics in the search… CONTINUE READING
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