Current treatment guidelines for acromegaly.

  title={Current treatment guidelines for acromegaly.},
  author={Shlomo Melmed and Imani M Jackson and David Kleinberg and Anne Klibanski},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={83 8},
Acromegaly, an indolent disorder of growth hormone (GH) hypersecretion is most typically caused by a somatotroph cell adenoma and may be treated by several modalities. Transsphenoidal surgical resection of micro-adenomas by experienced neurosurgeons results in biochemical normalization (postglucose GH <2 ng/mL, assay-dependent, age- and sex-matched IGF-I levels) in 70% of patients. However, over 65% of GH-secreting adenomas are invasive or macroadenomas, and over 50% of these patients have… CONTINUE READING


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The role of radiotherapy in acromegaly

  • AJ vanderLely
  • J Clin Endocrinal Metab
  • 1997
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