Current treatment approaches for mantle-cell lymphoma.

  title={Current treatment approaches for mantle-cell lymphoma.},
  author={Thomas E Witzig},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={23 26},
  • Thomas E Witzig
  • Published 2005 in
    Journal of clinical oncology : official journal…
Mantle-cell lymphoma (MCL) is now recognized as a distinct clinicopathologic subtype of B-cell non-Hodgkin's lymphoma. Patients with MCL are typically older adults with a male predominance and usually present with stage IV disease. The cells are characterized as CD20+ CD5+ CD23- with a t(11;14)(q13;q32) and cyclin D1 overexpression on immunohistochemistry. Response to chemotherapy usually results in a tumor response but unmaintained remissions are short and the median survival is 3 to 4 years… CONTINUE READING


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