Current thinking on genital herpes

@article{Hofstetter2014CurrentTO,
  title={Current thinking on genital herpes},
  author={Annika M Hofstetter and Susan L. Rosenthal and Lawrence R Stanberry},
  journal={Current Opinion in Infectious Diseases},
  year={2014},
  volume={27},
  pages={75–83}
}
Purpose of review Genital herpes has a high global prevalence and burden of disease. This manuscript highlights recent advances in our understanding of genital herpes simplex virus (HSV) infections. Recent findings Studies demonstrate a changing epidemiological landscape with an increasing proportion of genital herpes cases associated with HSV type 1. There is also growing evidence that the majority of infected individuals exhibit frequent, brief shedding episodes that are most often… Expand
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References

SHOWING 1-10 OF 158 REFERENCES
Recurrence Rates in Genital Herpes after Symptomatic First-Episode Infection
TLDR
The natural history of symptomatic recurrences in the complete population and in the subset of untreated patients is summarized. Expand
Changing epidemiology of herpes simplex virus infections.
  • R. Whitley
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2013
TLDR
Although antiviral therapies improved the quality of life, none prevented personto-person transmission or the establishment of latency, and Bernstein and colleagues have redefined the epidemiology of primary genital herpes, the disease has changed. Expand
Recent developments in anti-herpesvirus drugs.
TLDR
New drugs in clinical trials are reviewed and some of the problems hindering their progress are highlighted, including how can new compounds be progressed when the perceived market need is small but the medical need is great. Expand
Natural History of Genital Herpes Simplex Virus Type 1 Infection
TLDR
Genital HSV-1 recurs infrequently in most patients, and the rate decreases further in the subsequent years of infection, so determination of the viral type is important for patient counseling. Expand
Once-daily valacyclovir to reduce the risk of transmission of genital herpes*
TLDR
Once-daily suppressive therapy with valacyclovir significantly reduces the risk of transmission of genital herpes among heterosexual, HSV-2-discordant couples. Expand
Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults.
TLDR
This high frequency of short subclinical HSV reactivation in immunocompetent hosts strongly suggests that the peripheral mucosal immune system plays a critical role in clearing HSVs reactivations. Expand
Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons.
TLDR
Seropositivity for HSV-2 is associated with viral shedding in the genital tract, even in subjects with no reported history of genital herpes. Expand
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
TLDR
Frequent viral reactivation occurs within ganglia despite diverse and complementary host and viral mechanisms that predispose toward latency, suggesting that viral replication may be constantly occurring in a small minority of neurons at these sites. Expand
Psychological Symptoms Associated with Genital Herpes Virus Infections
TLDR
It is suggested that stress could lead to recurrences of genital herpes infection, but prospective studies have been unable to demonstrate any relationship between pre-existing stress and recurrence. Expand
Genital shedding of herpes simplex virus among men.
TLDR
The frequency of viral shedding in men with genital herpes appears comparable with that in women, and the shedding rate amongMen with genital HSV-2 was significantly higher than among men with herpes simplex virus type 2 infection. Expand
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