Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.

Abstract

Cell culture studies have indicated that the sequence of methotrexate (MTX) and 5-fluorouracil (5-FU) exposure influences cytotoxicity. Sequential MTX/5-FU shows synergistic effects in many cell lines, but the concentration of purines and thymidine are critical modulators of the outcome. Sequential 5-FU/MTX usually shows antagonistic cytotoxicity, and… (More)

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@article{Tattersall1983CurrentSO, title={Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.}, author={Martin Hn Tattersall}, journal={Seminars in oncology}, year={1983}, volume={10 2 Suppl 2}, pages={6-14} }