Current status of the anticoagulant hirudin: its biotechnological production and clinical practice

@article{Sohn2001CurrentSO,
  title={Current status of the anticoagulant hirudin: its biotechnological production and clinical practice},
  author={J. Sohn and H. Kang and K. Rao and C. Kim and E. Choi and B. Chung and S. Rhee},
  journal={Applied Microbiology and Biotechnology},
  year={2001},
  volume={57},
  pages={606-613}
}
  • J. Sohn, H. Kang, +4 authors S. Rhee
  • Published 2001
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
Abstract. Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech, Hirudo medicinalis. Owing to its high affinity and specificity for thrombin, hirudin has been intensively investigated for research and therapeutic purposes. The investigation of hirudin has contributed greatly to the understanding of the mode of action of thrombin and the clotting system. Hirudin and several hirudin analogues have also been demonstrated to have several advantages as a highly specific… Expand
Hirudin variants production by genetic engineered microbial factory
Production and Characterization of Hirudin Variant-1 by SUMO Fusion Technology in E. coli
Robust preparative-scale extracellular production of hirudin in Escherichia coli and its purification and characterization
Extracellular secretion of anticoagulant peptide hirudin in Lactococcus lactis using SP310mut2 signal peptide
Hirudin as a novel fusion tag for efficient production of lunasin in Escherichia coli
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 67 REFERENCES
...
1
2
3
4
5
...