Current status of clinical islet cell transplantation.

  title={Current status of clinical islet cell transplantation.},
  author={Jonathan Rt Lakey and Mohammadreza Mirbolooki and Andrew Mark James Shapiro},
  journal={Methods in molecular biology},
Clinical outcomes of pancreas transplantation were superior to that of islet transplantation until the introduction of the Edmonton protocol. Significant advances in islet isolation and purification technology, novel immunosuppression and tolerance strategies, and effective antiviral prophylaxis have renewed interest in clinical islet transplantation for the treatment of diabetes mellitus. The introduction of a steroid-free antirejection protocol and islets prepared from two donors led to high… CONTINUE READING

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