Current status of a unique vaccine preventing pregnancy.

  title={Current status of a unique vaccine preventing pregnancy.},
  author={Gursaran P. Talwar and Kripa N. Nand and Jagdish Chandra Gupta and Atmaram H. Bandivdekar and Radhey Shyam Sharma and Nirmal K. Lohiya},
  journal={Frontiers in bioscience},
The ability of a vaccine linking beta hCG to a carrier to generate antibodies against hCG, its reversibility and safety was established by Phase I clinical trials conducted in India, Finland, Sweden, Chile and Brazil. Employing a hetero-species dimer (beta hCG-αoLH) linked to tetanus toxoid further improved the immunogenicity of the vaccine. Phase II clinical trials showed that anti-hCG titres above 50 ng/ml prevented pregnancy of sexually active fertile women without derangement of ovulation… Expand
2 Citations
Modulation of Gonadotropins Activity by Antibodies
Antibodies are powerful tools that were largely used to decipher gonadotropins' actions and they have shown their utility as therapeutics in several other indications such as cancer. Expand


A vaccine that prevents pregnancy in women.
Evidence of the feasibility of a vaccine for control of human fertility is presented, consisting of a heterospecies dimer of the beta sub unit of human chorionic gonadotropin associated noncovalently with the alpha subunit of ovine luteinizing hormone, that induces antibodies of high avidity against hCG. Expand
Development of a highly immunogenic recombinant candidate vaccine against human chorionic gonadotropin.
A novel recombinant anti-hCG vaccine is reported which demonstrates improved immunogenicity and is expected to reduce cost as well as facilitate production of a molecularly consistent conjugate on a large scale. Expand
Mycobacterium indicus pranii is a potent immunomodulator for a recombinant vaccine against human chorionic gonadotropin.
MIP, a non-pathogenic Mycobacterium employed as an autoclaved suspension in aqueous buffer, significantly increased antibody titers in the FVB strain of mice, and the duration of the antibody response was lengthened. Expand
Carrier‐induced epitope‐specific regulation and its bypass in a protein‐protein conjugate
It is shown that preimmunization with TT causes a less profound reduction in anti‐hCG titers if the preim immunized mice are subsequently injected with αoLH‐βhCG conjugated to a synthetic tetanus toxin peptide recognized by TT‐induced and peptide‐induced T cells. Expand
Phase I clinical trials with three formulations of anti-human chorionic gonadotropin vaccine.
Results indicate that none of the three beta-hCG-based contraceptive vaccines had any adverse effects clinically, on endocrine status and metabolic parameters, and further work can be undertaken to study the efficacy of these vaccines in humans for preventing pregnancy. Expand
Active Immunization of Rhesus Monkeys Against the β-Subunit of Ovine Luteinizing Hormone: Evaluation of Safety and Effectiveness of an Antigonadotropin Vaccine
The possibility of active immunization with the β-subunit or fragments of HCG as a method of fertility regulation in females has been investigated for almost two decades and several anti-HCG vaccines have reached the stage of phase I clinical trials. Expand
Antibody response to Pr-beta-HCG-TT vaccine in human subjects.
Antibody response to processed beta human chorionic gonadotropin tetanus toxoid vaccine (Pr-beta-HCG-TT) was investigated in 4 human subjects who were in reproductive age and of proven fertility and had undergone tubal ligations, indicating the reversibility of antibody response with this vaccine. Expand
Safety Evaluation of HCG Vaccine in Primates: Autoantibody Production
The immediate objective of this investigation was to evaluate the possible production of autoantibodies after immunization of baboons with a vaccine prepared from the C-terminal peptide of theExpand
An improved immunogen for anti-human chorionic gonadotropin vaccine eliciting antibodies reactive with a conformation native to the hormone without cross-reaction with human follicle stimulating hormone and human thyroid stimulating hormone.
The properties and merits of the antibodies induced by this HSD and beta hCG linked to carrier(s) were investigated in rodents and in a subhuman primate species and none of the sera gave any evidence of cross-reactivity with human follicle stimulating hormone (hFSH) and human thyroid stimulating hormone (£TSH). Expand
Observations on the antigenicity and clinical effects of a candidate antipregnancy vaccine: beta-subunit of human chorionic gonadotropin linked to tetanus toxoid.
Clinical surveillance and immunologic, hematologic, and biochemical tests indicated excellent local and systemic tolerance to the antigen, and no significant adverse effects on menstrual function, endocrine status, or health were found. Expand