Current status and potential application of ISCOMs in veterinary medicine.

  title={Current status and potential application of ISCOMs in veterinary medicine.},
  author={Bror Morein and Ke-fei Hu and Izzeldin A. Abusugra},
  journal={Advanced drug delivery reviews},
  volume={56 10},
The immune stimulating complex (ISCOM) is a 40 nm nanoparticle used as a delivery system for vaccine antigens, targeting the immune system both after parenteral and mucosal administration. The ISCOM is made up of saponin, lipids and antigen usually held together by hydrophobic interaction between these three components. The compulsory elements to form the ISCOM structure are cholesterol and saponin. When the antigen is omitted the ISCOM-MATRIX is formed. There are a number of saponins that can… CONTINUE READING


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