Current status and future potential of transdermal drug delivery

  title={Current status and future potential of transdermal drug delivery},
  author={Mark R. Prausnitz and Samir Mitragotri and Robert Langer},
  journal={Nature Reviews Drug Discovery},
The past twenty five years have seen an explosion in the creation and discovery of new medicinal agents. Related innovations in drug delivery systems have not only enabled the successful implementation of many of these novel pharmaceuticals, but have also permitted the development of new medical treatments with existing drugs. The creation of transdermal delivery systems has been one of the most important of these innovations, offering a number of advantages over the oral route. In this article… 
Design Development and Evaluation of Transdermal Drug Delivery System of Antipyretic Agent
Transdermal drug delivery is an enthusiastic and demanding area and the development of such a type of novel drug delivery system not only enhances the performance of the International Journal of Pharma Research and Health Sciences, but also contributes to the quality of the publication.
The transdermal revolution.
Ethosomes-Newer Trend in Transdermal Drug Delivery: A Review
The first transdermal system for systemic delivery—a three-day patch that delivers scopolamine to treat motion sickness—was approved for use in the United States in 1979 and a decade later, nicotine patches became the first transDermal blockbuster, raising the profile of International Journal of Pharma Research and Health Sciences.
Challenges and opportunities in dermal/transdermal delivery.
Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications.
Identifying present challenges to reliable future transdermal drug delivery products.
  • S. Giannos
  • Biology, Engineering
    Therapeutic delivery
  • 2015
A number of methods and technologies have been conceived to overcome the skin barrier, including mechanical, chemical and thermal permeation enhancement techniques, as well as future directions for transdermal therapies.
Current Trends in Pharmaceutical Sciences Protein Delivery : Is Iontophoresis a Feasible Option ?
Recent development in transdermal iontophoresis is an attempt to evaluate recent development and the possibilities with it.
Transdermal delivery of methotrexate: past, present and future prospects.
The past, present and future of transdermal delivery of methotrexate is discussed, including chemical enhancers, iontophoresis, electroporation, ultrasound and microneedles, either alone or in combination.
Peptide-Mediated Transdermal Drug Delivery
This chapter focuses on the use of peptides as novel transdermal drug delivery agents, and discusses the potential of both the cell- penetrating and membrane-penetrating peptides in delivering a wide variety of cargoes ranging from proteins and peptide therapeutics, nanoparticles, and nucleotides across the skin.
Turning Theory into Practice: The Development of Modern Transdermal Drug Delivery Systems and Future Trends
The evolution of transdermal therapeutic systems over the years and the potential of newer transDermal technologies to deliver hydrophilic drugs and macromolecules through the skin are discussed.


Transdermal delivery of peptide and protein drugs: An overview
Recent work in the area of transdermal peptide and protein drug delivery is overviewed, including strategies such as prodrugs, chemical enhancement, iontophoresis, electroporation, and ultrasound, with focus on mass-transport mechanisms of different systems.
Synergistic Effect of Enhancers for Transdermal Drug Delivery
This paper summarizes literature studies on these combinations of iontophoresis, chemicals, ultrasound, and electroporation that have been found to enhance transdermal transport more effectively than each of them alone.
Ultrasound-mediated transdermal protein delivery
Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.
Transdermal Delivery of Antisense Oligonucleotides with Microprojection Patch (macroflux®) Technology
It is demonstrated that microprojection patch technology can facilitate the controlled transdermal ODN delivery in mice and rats through the stratum corneum.
Discovery of transdermal penetration enhancers by high-throughput screening
These studies show the feasibility of using penetration enhancers for systemic delivery of macromolecular drugs from a transdermal patch by increasing skin permeability by up to ∼100-fold without inducing skin irritation.
Transdermal drug delivery : developmental issues and research initiatives
The biochemistry of the skin and its role in assessing potential drug interactions, chemical and electrical attempts to enhance percutaneous absorption and transdermal drug delivery, selection of drug candidates and methods for delivery, and areas requiring further inves are examined.
Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery.
This review compiles the various CPE used for the enhancement of TDD, the mechanism of action of different chemical enhancers and the structure-activity relationship of selected and extensively studied enhancers such as fatty acids, fatty alcohols and terpenes.
Rapid Temporal Control of Transdermal Drug Delivery by Electroporation
This study focuses on the rapid kinetics of transdermal transport by electroporation, which may allow rapid onset of therapeutic action and/or complex drug delivery profiles duringtransdermal drug delivery.
Microfabricated microneedles: a novel approach to transdermal drug delivery.
These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.
Overview and Evolution of Therapeutic Systems
  • A. Zaffaroni
  • Biology
    Annals of the New York Academy of Sciences
  • 1991
The systems' design concept incorporated a reservoir isolating drug from the body, a rate controller, an energy source, and a platform, which considered them not devices but rate- and duration-controlled drug products requiring Food and Drug Administration approval.