Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications.

@article{Yin2014CurrentSO,
  title={Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications.},
  author={Peiyuan Yin and Guowang Xu},
  journal={Journal of chromatography. A},
  year={2014},
  volume={1374},
  pages={
          1-13
        }
}
  • Peiyuan Yin, Guowang Xu
  • Published 2014
  • Chemistry, Medicine
  • Journal of chromatography. A
  • Metabolomics, as a part of systems biology, has been widely applied in different fields of life science by studying the endogenous metabolites. The development and applications of liquid chromatography (LC) coupled with high resolution mass spectrometry (MS) greatly improve the achievable data quality in non-targeted metabolic profiling. However, there are still some emerging challenges to be covered in LC-MS based metabolomics. Here, recent approaches about sample collection and preparation… CONTINUE READING
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