Current state and perspectives of 3D-QSAR.

  title={Current state and perspectives of 3D-QSAR.},
  author={Miki Akamatsu},
  journal={Current topics in medicinal chemistry},
  volume={2 12},
  • Miki Akamatsu
  • Published 2002 in Current topics in medicinal chemistry
Quantitative structure-activity relationships (QSAR) have played an important role in the design of pharmaceuticals and agrochemicals. All QSAR techniques assume that all the compounds used in analyses bind to the same site of the same biological target. However, each method differs in how it describes structural properties of compounds and how it finds the quantitative relationships between the properties and activities. The Hansch-Fujita approach, the so-called classical QSAR, is a… CONTINUE READING
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