Current prospects for RNA interference-based therapies

  title={Current prospects for RNA interference-based therapies},
  author={Beverly L. Davidson and Paul B. McCray},
  journal={Nature Reviews Genetics},
RNA interference (RNAi) is a powerful approach for reducing expression of endogenously expressed proteins. It is widely used for biological applications and is being harnessed to silence mRNAs encoding pathogenic proteins for therapy. Various methods — including delivering RNA oligonucleotides and expressing RNAi triggers from viral vectors — have been developed for successful RNAi in cell culture and in vivo. Recently, RNAi-based gene silencing approaches have been demonstrated in humans, and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
266 Citations
191 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 266 extracted citations


Publications referenced by this paper.
Showing 1-10 of 191 references

matchmaking for Argonautes

  • B. Czech, Hannon, G. J. Small RNA sorting
  • Nature Rev. Genet. 12, 19–31
  • 2011

progress and challenges

  • F. Mingozzi, High, K. A. Therapeutic in vivo gene transfer for genetic d AAV
  • Nature Rev. Genet. 12, 341–355
  • 2011

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

  • J DeVincenzo
  • Proc. Natl Acad. Sci. USA 107,
  • 2010

A role for human Dicer in pre-RISC loading of siRNAs

  • K Sakurai
  • Nucleic Acids Res
  • 2010

Similar Papers

Loading similar papers…