Current prospects for RNA interference-based therapies

@article{Davidson2011CurrentPF,
  title={Current prospects for RNA interference-based therapies},
  author={Beverly L. Davidson and Paul B. McCray},
  journal={Nature Reviews Genetics},
  year={2011},
  volume={12},
  pages={329-340}
}
RNA interference (RNAi) is a powerful approach for reducing expression of endogenously expressed proteins. It is widely used for biological applications and is being harnessed to silence mRNAs encoding pathogenic proteins for therapy. Various methods — including delivering RNA oligonucleotides and expressing RNAi triggers from viral vectors — have been developed for successful RNAi in cell culture and in vivo. Recently, RNAi-based gene silencing approaches have been demonstrated in humans, and… CONTINUE READING

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