Current prospective management of patients with osteonecrosis drug-induced (bisphosphonates) of the jaws: our experience

@inproceedings{Giudice2010CurrentPM,
  title={Current prospective management of patients with osteonecrosis drug-induced (bisphosphonates) of the jaws: our experience},
  author={Mario Giudice and Maria Giulia Cristofaro},
  year={2010}
}
Background Bisphosphonates (BP) are frequently used for the treatment of multiple myeloma, bone metastasis and for osteoporosis, the most used are Alendronic and Zolendronic acids (1). This type of drugs, especially Zolendronic acid, pointed out a serious side effect: ostenecrosis of the jaws (ONJ). It is demonstrated they reduce bone turn-over and induce apoptosis of the osteoclasts. BP have remarkable ability of anti-angiogenesis, that together to micro-traumas and inflammations, it can be a… CONTINUE READING