Current progress in the chemistry, medicinal chemistry and drug design of artemisinin based antimalarials.

@article{Vroman1999CurrentPI,
  title={Current progress in the chemistry, medicinal chemistry and drug design of artemisinin based antimalarials.},
  author={Jeffrey A Vroman and Maria Alvim-Gaston and Mitchell A. Avery},
  journal={Current pharmaceutical design},
  year={1999},
  volume={5 2},
  pages={
          101-38
        }
}
This review covers developments in relation to artemisinin-based antimalarial agents. Topics covered include a brief introduction to the history and treatment of malaria, and more recently, drug resistant malaria; the discovery of the naturally occurring novel peroxidic antimalarial artemisinin; artemisinin biosynthesis, metabolism and biotransformations; the diversity of proposed mechanisms of action; pharmacokinetics; the insight into structure-toxicity relationships; the total syntheses and… CONTINUE READING
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