Current problems with non-specific COX inhibitors.

@article{McGettigan2000CurrentPW,
  title={Current problems with non-specific COX inhibitors.},
  author={Patricia McGettigan and Darren Henry},
  journal={Current pharmaceutical design},
  year={2000},
  volume={6 17},
  pages={
          1693-724
        }
}
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and effective treatments for pain and inflammation. They have a substantial toxicity profile with side effects mainly affecting the gastrointestinal tract, heart and kidneys. Although they comprise a chemically diverse group of drugs, NSAIDs are unified by a common mode of action the ability to inhibit the enzyme cyclo-oxygenase (COX). This also accounts for much of their toxicity. The enzyme exists in at least 2 isoforms. COX-1… CONTINUE READING
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