Current prevalence of HTLV‐1 in Japan as determined by screening of blood donors

@article{Satake2012CurrentPO,
  title={Current prevalence of HTLV‐1 in Japan as determined by screening of blood donors},
  author={Masahiro Satake and Kazunari Yamaguchi and Kenji Tadokoro},
  journal={Journal of Medical Virology},
  year={2012},
  volume={84}
}
Human T‐cell leukemia virus type‐1 (HTLV‐1), a major source of adult T‐cell leukemia and related diseases, is endemic to southwestern Japan. Mother‐to‐infant transmission via breast milk is an important route of infection, and establishing programs to prevent such transmission requires exact figures on the HTLV‐1 prevalence rate and the number of carriers. Therefore, the seroprevalence of HTLV‐1 among 1,196,321 Japanese first‐time blood donors from 2006 to 2007 was investigated. A total of 3… 
Epidemiology of HTLV-1 Infection and ATL in Japan: An Update
  • M. Iwanaga
  • Medicine, Biology
    Frontiers in Microbiology
  • 2020
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Seroprevalence of Human T-Cell Lymphotropic Virus-1/2 in Blood Donors in Northern Pakistan: Implications for Blood Donor Screening.
OBJECTIVE To determine the seroprevalence of Human T-cell Lymphotropic Virus-1/2 (HTLV-1/2) in blood donors in Northern Pakistan. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Armed
Analysis of HTLV‐1 proviral load (PVL) and antibody detected with various kinds of tests in Japanese blood donors to understand the relationship between PVL and antibody level and to gain insights toward better antibody testing
TLDR
There was a large discrepancy in antibody titer among 13 provirus‐positive samples, probably suggesting that antibody‐based screening tests should incorporate multiple HTLV‐1 antigens, such as Gag and Env antigen.
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References

SHOWING 1-10 OF 42 REFERENCES
Trends in HTLV‐1 prevalence and incidence of adult T‐cell leukemia/lymphoma in Nagasaki, Japan
TLDR
The present study estimated the number of HTLV‐1 carriers in Nagasaki City based on the seroprevalence rates in a hospital‐based population from Nagasaki University Hospital, and found that there is a large pool of HT LV carriers aged over 70 years, and a continuing development of cases of ATLL among the elderly is therefore expected.
Prevention of transmission of human T‐lymphotropic virus type 1 (HTLV‐1) through transfusion, by donor screening with antibody to the virus One‐year experience
TLDR
It is proposed that all donor blood in areas where HTLV‐1 is endemic be screened by PA before transfusion, and PA‐positive blood units should be reexamined by IF or Western blot testing to reduce the amount of wasted blood.
The prevalence of human T-cell lymphotropic virus type 1 in the general population is unknown.
TLDR
There is a paucity of general population data from countries in which human T-cell lymphotropic virus type 1 is endemic, and that new studies are required to reevaluate the global burden of infection.
Sexual transmission of human T-lymphotropic virus type I (HTLV-I).
TLDR
The data are consistent with the lower efficiency of female-to-male sexual transmission of HTLV-I, but penile ulcers or concurrent syphilis may increase a man's risk of infection.
The 4th nation‐wide study of adult T‐cell leukemia/lymphoma (ATL) in Japan: Estimates of risk of ATL and its geographical and clinical features
  • K. Tajima
  • Medicine
    International journal of cancer
  • 1990
TLDR
To clarify the chronological changes and geographical variations in the annual incidence of ATL in Japan, continuous systematic surveillance is necessary and further nation‐wide studies are being prepared.
Prevalence of antibody to human T-cell lymphotropic virus type I in Okinawa, Japan, after an interval of 9 years.
TLDR
Seroepidemiologic studies at a 9-year interval on residents of Yonaguni Island, Okinawa, Japan suggest that higher rates of HTLV-I infection in adults reflect past high rates of infection as infants, and that there were few new cases of HT LV infection and none in the lower age groups over the 9 years.
Significance of Postnatal Mother‐to‐Child Transmission of Human T‐lymphotropic Virus Type‐I on the Development of Adult T‐cell Leukemia/Lymphoma
TLDR
Sera of school children in a highly endemic town on two separate occasions at a 6‐year interval suggested that carrier rates of children at certian ages are reflected by the date of birth rather than by age.
The Seroepidemiology of Human T-Lymphotropic Viruses: Types I and II in Europe: A Prospective Study of Pregnant Women
TLDR
Pregnant women better reflect the general population than blood donors or IDUs and provide a robust baseline against which changes in HTLV-I andHTLV-II seroprevalence in Europe can be measured.
Findings from the Miyazaki Cohort Study.
  • N. Mueller, A. Okayama, S. Stuver, N. Tachibana
  • Medicine, Biology
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1996
TLDR
By identifying subclinical markers of pathogenesis, the Miyazaki Cohort Study hopes to provide the foundation for developing interventions to prevent HTLV-I-associated disease.
Adult T-cell leukemia in Japan.
  • K. Takatsuki, M. Matsuoka, K. Yamaguchi
  • Biology, Medicine
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1996
Adult T-cell leukemia (ATL) was first reported in Japan, where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is found to be the
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