Current pharmacotherapeutic concepts for the treatment of cardiovascular disease in diabetics

  title={Current pharmacotherapeutic concepts for the treatment of cardiovascular disease in diabetics},
  author={Peter Highlander and Graham P. Shaw},
  journal={Therapeutic Advances in Cardiovascular Disease},
  pages={43 - 54}
With the growing worldwide obesity epidemic, obesity, type 2 diabetes mellitus and hypertension leading to premature cardiovascular events, are increasingly prevalent. Diabetes mellitus is a significant public health concern and more aggressive management of the condition and its complications, particularly cardiovascular disease, is warranted. Endothelial cell dysfunction is now known to be present at the earliest stages of metabolic syndrome, and insulin resistance and may precede the… 

Influences of diabetes on the development and progression of cardiovascular disease

The March/April 2010 issue of the British Journal of Diabetes & Vascular Disease discusses the management of cardiovascular complications in diabetes and introduces myself as a new member of the editorial team of the journal.

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In order to optimally reduce the risk for cardiovascular events in the patient with diabetes and hypertension, optimal BP control should be coupled with comprehensive lifestyle modification and aggressive management of dyslipidemia and hyperglycemia.

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Vascular endothelium is focused on as a target of the prostaglandin I2 analog beraprost sodium and the peroxisome proliferators-activated receptor α activator fenofibrate for the prevention and treatment of atherosclerosis in patients with type 2 diabetes mellitus.

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A target-driven, long-term, intensified intervention aimed at multiple risk factors in patients with type 2 diabetes and microalbuminuria reduces the risk of cardiovascular and microvascular events by about 50 percent.

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A characteristic pattern, termed diabetic dyslipidemia, consists of low high density lipoprotein (HDL), increased triglycerides, and postprandial lipemia, most frequently seen in type 2 diabetes and may be a treatable risk factor for subsequent cardiovascular disease.

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