Current perspective on the role of apoptosis in atherothrombotic disease.


Thrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads to vessel occlusion and acute ischemia. In this current perspective, we present evidence for apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may directly affect blood thrombogenicity through the release of apoptotic cells and microparticles into the bloodstream.

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@article{Mallat2001CurrentPO, title={Current perspective on the role of apoptosis in atherothrombotic disease.}, author={Ziad Mallat and Alain Tedgui}, journal={Circulation research}, year={2001}, volume={88 10}, pages={998-1003} }