Current mouse and cell models in prostate cancer research.

@article{Wu2013CurrentMA,
  title={Current mouse and cell models in prostate cancer research.},
  author={Xinyu Wu and Shiaoching Gong and Pradip Roy-Burman and Peng Lee and Zoran Culig},
  journal={Endocrine-related cancer},
  year={2013},
  volume={20 4},
  pages={
          R155-70
        }
}
Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an androgen-regulated fusion protein, revealed its role in developing PCa precursor lesions, prostate intraepithelial neoplasia; however, it is not sufficient for PCa development… CONTINUE READING

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