Current methods of gene prediction, their strengths and weaknesses.

@article{Math2002CurrentMO,
  title={Current methods of gene prediction, their strengths and weaknesses.},
  author={Catherine Math{\'e} and Marie-France Sagot and Thomas Schiex and Pierre Rouz{\'e}},
  journal={Nucleic acids research},
  year={2002},
  volume={30 19},
  pages={
          4103-17
        }
}
While the genomes of many organisms have been sequenced over the last few years, transforming such raw sequence data into knowledge remains a hard task. A great number of prediction programs have been developed that try to address one part of this problem, which consists of locating the genes along a genome. This paper reviews the existing approaches to predicting genes in eukaryotic genomes and underlines their intrinsic advantages and limitations. The main mathematical models and… CONTINUE READING

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