Current management and challenges of malignant disease in the CNS in paediatric leukaemia.

@article{Pui2008CurrentMA,
  title={Current management and challenges of malignant disease in the CNS in paediatric leukaemia.},
  author={Ching-Hon Pui and Scott C. Howard},
  journal={The Lancet. Oncology},
  year={2008},
  volume={9 3},
  pages={257-68}
}
With 5-year event-free survival of 80% now commonplace for paediatric acute lymphoblastic leukaemia (ALL), and 50% for paediatric acute myeloid leukaemia (AML), recent efforts have focused on optimum risk-directed treatment. Because cranial irradiation can cause many acute and late complications (eg, second cancers, neurocognitive deficits, endocrine disorders, and growth impairment), it has been largely replaced by intensive intrathecal treatment and systemic chemotherapy. Prophylactic cranial… CONTINUE READING