Current limitations and future opportunities for prediction of DILI from in vitro

@article{Funk2016CurrentLA,
  title={Current limitations and future opportunities for prediction of DILI from in vitro},
  author={Christoph Funk and Adrian Roth},
  journal={Archives of Toxicology},
  year={2016},
  volume={91},
  pages={131-142}
}
Drug-induced liver injury (DILI) is a major concern for drug developers, regulators and clinicians. It is triggered by drug and xenobiotic insults leading to liver impairment or damage, in the worst-case liver failure. In contrast to acute “intrinsic” hepatotoxicity, DILI typically manifests in a very small subset of the population under treatment with no clear dose relationship and inconsistent temporal patterns and is therefore termed an idiosyncratic event. Involved are multifactorial… CONTINUE READING
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