Current knowledge of heritable tumors.

Abstract

The consolidation of formal genetic, epidemiologic, cytogenetic and molecular genetic data has provided a complementary model that invokes the unmasking of recessive predisposing mutations by aberrant mitotic events. This model proposes the fixation of monoallelic genetic damage and, subsequently, its elucidation through mitotic malsegregation or… (More)

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@article{Cavenee1989CurrentKO, title={Current knowledge of heritable tumors.}, author={Webster K Cavenee}, journal={Birth defects original article series}, year={1989}, volume={25 2}, pages={29-43} }