Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going.


Impaired insulin secretion (beta-cell), increased hepatic glucose production (liver), and decreased peripheral (muscle) glucose utilization constitute the traditional primary defects responsible for the development and progression of type 2 diabetes mellitus. beta-Cell failure, ultimately leading to decreased insulin secretion, is now known to occur much… (More)
DOI: 10.1016/j.amjmed.2009.12.008


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