Current issues in the enzymology of mitomycin C metabolic activation.

  title={Current issues in the enzymology of mitomycin C metabolic activation.},
  author={Victoria J. Spanswick and Jeffrey Cummings and John F. Smyth},
  journal={General pharmacology},
  volume={31 4},
1. Mitomycin C (MMC) is considered to be the prototype bioreductive drug undergoing activation to toxic species preferentially under hypoxic conditions. Therefore a proper understanding of the enzymology of bioreduction in tumor tissue is of great importance. 2. DT-diaphorase and NADPH:cytochrome P-450 reductase (quinone reductases) are believed to have established roles in this activation pathway, but these roles are now undergoing revision. 3. It is emerging, however, that different… CONTINUE READING


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