Current issues in the design and analysis of stepped wedge trials.

Abstract

The use of stepped wedge designs in cluster-randomized trials and implementation studies has increased rapidly in recent years but there remains considerable debate regarding the merits of the design. We discuss three key issues in the design and analysis of stepped wedge trials - time-on-treatment effects, treatment effect heterogeneity and cohort studies. 
DOI: 10.1016/j.cct.2015.07.006

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